BH3 proteinsReplication stressRecent studies indicate that replication checkpoint modulators (RCMs) such as inhibitors of CHK1, ATR, and WEE1 have promising monotherapy activity in solid tumors, including platinum-resistant high grade serous ovarian cancer (HGSOC). However, clinical response rates are...
Yang X, Xiang X, Xia M, Su J, Wu Y, Shen L, Xu Y and Sun L: Inhibition of JNK3 promotes apoptosis induced by BH3 mimetic S1 in chemoresistant human ovarian cancer cells. Anat Rec (Hoboken) 298: 386-395, 2015.Yang X, Xiang X, Xia M, et al. Inhibition of JNK3 promotes ...
Li. 2005. Activity deprivation-dependent induction of the proapoptotic BH3-only protein Bim is independent of JNK/c-Jun activation during apoptosis in cerebellar granule neurons. Neu- rosci. Lett. 375:7-12. (First published 24 November 2004; doi:10.1016/j. neulet.2004.10.082.)....
目的:观察木犀草素(luteolin,Lut)是否通过ERK1/2及JNK通路对缺血/再灌注(ischemia-reperfusion,I/R)成年大鼠离体心脏及单个心肌细胞的收缩功能具有改善作用,并探讨具体的机制.通过检测血流动力学,心肌梗死面积,LDH释放量,单个心肌细胞的收缩功能,TUNEL,以及凋亡和收缩相关蛋白表达等指标,验证木犀草素的心肌保护作用......
POSH REGULATES JNK ACTIVATION BY THE BH3-ONLY PROTEIN NIX.: 64PopulationAn abstract is unavailable.doi:10.1097/00003246-200512002-00064Michael WilhelmStephen GireZhiheng XuNickolay V KukekovLloyd A GreeneCritical Care Medicine
Subterranean caves in the Chihuahuan Desert were frequently used by the pre-Hispanic population to deposit their dead. This paper re-examines the documentation and artifactual material from f...